Dr. Ma. Daisy Pedroso-Tabuena

Details

Sex: Female
Education:

Electromyography and Dystonia, University of Tokushima, 2004
Post-Graduate Fellowship Training in Electromyography, University of Tokushima, 2003
Fellowship in Neurology, University of the East - Ramon Magsaysay Memorial Hospital, 1999
Residency, West Visayas State University Hospital, 1995
Doctor of Medicine, West Visayas State University, 1991
Bachelor of Science in Biology, University of San Agustin, 1987

Field of Specialization
Internal Medicine
Adult Neurologist
Electromyography and Nerve Conduction Studies

Researches:

Article title: Evaluation of loop-mediated isothermal amplification test kit (TB Lamp) for the diagnosis of pulmonary tuberculosis in a tertiary hospital in Iloilo City: Retrospective Study
Authors: Rollin P Tabuena, Jiggy Leonard F. Landong, Ma. Daisy P. Tabuena, Earl Joshua G. Alcantara and Ma. Theresa Crisanta L. Anayan
Publication title: Chest Infections 164(4), Supplement October 2023

Purpose: For a very long time, the public health of the entire world has been seriously threatened by tuberculosis (TB). WHO’s End TB Strategy calls for the early diagnosis of TB. A commercial molecular assay, the Loopamp^TM Mycobacterium tuberculosis complex (MTBC) detection kit uses loop-mediated isothermal amplification (LAMP), and is referred to as TB-LAMP. Because of its limited infrastructure requirements and relative ease of use, TB-LAMP is being explored for use as a rapid diagnostic test. This study will determine the sensitivity and specificity of TB-LAMP in diagnosing Pulmonary Tuberculosis in a Tertiary Hospital in Iloilo City

This study will determine the accuracy of Loop-Mediated Isothermal Amplification Test Kit (TB-LAMP) in the diagnosis of pulmonary tuberculosis in a tertiary hospital in Iloilo City.

Methods: Design: Retrospective, Cross-Sectional

Setting: Iloilo Mission Hospital, Iloilo City, Philippines

Population: All patients at Iloilo Mission Hospital from January 1, 2019 until December 31, 2021 who were diagnosed as having Pulmonary Tuberculosis based on the inclusion and exclusion criteria of this study.

Maneuvers: Chart review of patients with PTB was done and information were collected for analysis. Demographic and clinical data, as well as results of TB-LAMP, DSSM and GeneXpert were studied and coded for statistics and were analyzed using Pearson chi-square test and Cramer’s V.

Results: This study included a total of 106 patients. 105 had DSSM results, 41 had GX results, and 76 of them had TB-LAMP results. The TB-LAMP had 100% sensitivity and specificity when compared to DSSM. When the data were examined closely, an association was discovered between DSSM and TB-LAMP (X2(4)> = 69.996, p =.000). And Cramer's V of.575 with p =.000

Conclusions: The TB-LAMP in this study had 100% sensitivity and specificity when compared to GeneXpert. When the data were examined closely, an association was discovered between LAMP and GeneXpert (X2(4)> = 45.399, p =.000). And Cramer's V of.463 with p =.000.

Clinical Implications: The findings of this study demonstrated that TB-LAMP is a reliable and useful diagnostic test for pulmonary tuberculosis. It has the same accuracy as GeneXpert and DSSM in the diagnosis of pulmonary tuberculosis, so TB-LAMP could be used as an alternative diagnostic test.

The findings of this study could help improve current guidelines for the diagnosis and treatment of patients with pulmonary tuberculosis
Full text available upon request to the author

Article title: Ataxia with vitamin E deficiency in the Philippines : A case report of two siblings
Authors: Ma Daisy Tabuena, Ryoma Morigaki, Ryosuke Miyamoto, Hideo Mure, Nobuaki Yamamoto, Kazuhisa Miyake, Taku Matsuda, Yuishin Izumi, Yasushi Takagi, Rollin P Tabuena, Toshitaka Kawarai
Publication title: The Journal of Medical Investigation 68(3.4):400-403, 2021

Abstract:
Here we report two siblings with ataxia and peripheral neuropathy. One patient showed head tremors. Genetic analysis revealed a mutation in the hepatic α-tocopherol transfer protein (α-TTP) gene (TTPA) on chromosome 8q13. They were diagnosed with ataxia with vitamin E deficiency which is firstly reported in the Philippines. As the symptoms of ataxia with vitamin E deficiency can be alleviated with lifelong vitamin E administration, differential diagnosis from similar syndromes is important. In addition, ataxia with vitamin E deficiency causes movement disorders. Therefore, a common hereditary disease in the Philippines, X-linked dystonia-parkinsonism, could be another differential diagnosis. The Philippines is an archipelago comprising 7,107 islands, and the prevalence of rare hereditary diseases among the populations of small islands is still unclear. For neurologists, establishing a system of genetic diagnosis and counseling in rural areas remains challenging. These unresolved problems should be addressed in the near future. J. Med. Invest. 68 : 400-403, August, 2021.
Full text available upon request to the author

Article title: Depression in X-linked dystonia-parkinsonism: a case-control study
Authors: Ryoma Morigaki, Masahito Nakataki, Toshitaka Kawarai, Lillian V Lee, Rosalia A Teleg, Ma Daisy P Tabuena, Hideo Mure, Wataru Sako, Paul Matthew D Pasco, Shinji Nagahiro, Junichi Iga, Tetsuro Ohmori, Satoshi Goto, Ryuji Kaji
Publication title: Parkinsons and Related disorders 19(9): 844-6, 2013