Dr. Baldomero Olivera, Jr. is recognized for his significant studies and accomplishments in the field of biochemistry and molecular biology, specifically the discoveries of numerous Conus peptides which are now in various phases of clinical trials as highly specific drugs for pain, epilepsy, and other disorders of the nervous system. His researches on marine gastropods and his keen sense of observation have led to the elucidation of the mechanism of action, functions, and classification of the neuroactive Conus peptides into families and superfamilies. Dr. Olivera serves as an inspiration to Filipino biochemists and other scientists, as he, since the early stages of his career, has contributed significantly to the growth of molecular biology and biotechnology with his isolation and characterization of the key enzymes such as DNA ligase and the DNA polymerase. He has been very generous in sharing his expertise with students, research assistants and faculty members of various universities; he has helped obtain fellowships for their training here and abroad, and has maintained a partnership and collaboration with the University of the Philippines Marine Science Institute in the country for more than three decades.
Sex: Male
Education:
- California Institute of Technology, USA, Ph.D. in Biophysical Chemistry, 1966
- University of the Philippines, Diliman, Quezon City, B.S. Chemistry, 1960
- Stanford University, Post-Doctoral (Biochemistry), 1968
- Cornell University, USA, M.S., 1958
Field of Specialization:
Biochemistry, Molecular Neuroscience, Molluscan Biodiversity, Toxinology and drug discovery, Neuropharmacology
Researches:
Olivera, B.M., Walker, C., Cartier, G.E., Hooper, D., Santos, A.D., et al., (1999) Speciation of cone snails and interspecific hyperdivergence of their venom peptides: potential evolutionary significance on introns
Annals of New York Academy of Science Volume 870
Monje, V.D., Ward, R., Olivera, B.M., Cruz, L.J. , (1999) 16S mitochondrial ribosomal RNA gene sequences: a comparison of seven Conus species
Philippine Journal of Science Volume 128
Olivera, B.M., (1999) The subfamily Turrinae in the Philippines: The genus Turris (Roding, 1798)
Philippine Journal of Science Volume 128, No. 4
Craig, A.G., Jimenez, E.C., Dykert, J., Nielsen, D.B., Gulyas, J., Abogadie, F.C., Porter, J., Rivier, J.E., Cruz, L.J., Olivera, B.M., McIntosh, J.M., (1997) A novel post-translational modification involving bromination of tryptophan: identification of the residue, L-6-bromotryptophan, in peptides from Conus imperialis and Conus radiatus venom
Journal of Biological Chemistry Volume 272
Craig, A.J., Norberg, T., Griffin, D., Hoeger, C., Akhtar, M., Schmidt, K., Low, W., Dykert, J., Richelson, E., Navarro, V., Macella, J., Watkins, J., Hillyard, D., Imperial, J., Cruz, L.J., Olivera, B.M., (1999) Contulakin-G, an O-glycosylated invertebrate neurotensin
Journal of Biological Chemistry Volume 274
England, L.J., Imperial, J., Jacobsen, R., Craig, A.G., Gulyas, J., Akhtar, M., Rivier, J., Julius, D., Olivera, B.M., (1998) Inactivation of a seronin-gated ion channel by a polypeptide toxin from marine snails
Science Volume 281
Jimenez, E.C., Craig, A.G., Watkins, M., Hillyard, D.R., Gray, W.R., Gulyas, J., Rivier, J.E., Cruz, L.J., Olivera, B.M., (1997) Bromocontryphan: post-translational bromination of tryptophan
Biochemistry Volume 36
McIntosh, J.M. Olivera, B.M., Cruz, L.J. Gray, W. R., (1984) y-Carboxyglutamate in a neuroactive toxin
Journal of Biological Chemistry Volume 259
McIntosh, J.M., Santos, A.D., Olivera, B.M., (1999) Conus peptides targeted to specific nicotinic acetylcholine receptor subtypes
Annual Review of Biochemistry Volume 68
Olivera, B.M., (1997) Conus venom peptides, receptor and ion channel targets and drug design: 50 million years of neuropharmacology
Molecular Biology Cell Volume 8
Olivera, B.M. et al., (1990) Diversity of Conus neuropeptides
Science Volume 249
Lirazan, M.B., Grey Craig, A., Shetty R., Walker, C.S., Olivera, B.M., Cruz, L.J., (1999) Multiple bromotryptophan and y-carboxyglutamate residues in Conus peptide
Philippine Journal of Science Volume 128, No. 3
Rechsteiner, M., Hillyard, D., and Olivera, B.M. , (1975) Turnover of nicotinamide adenine dinucleotide in cultures of human cells
Journal of Cell Physiology Volume 88
Lirazan, M., Jimenez, E.C., Grey, Craig, A., Olivera, B.M., Cruz, L.J., (2002) Conophysin-R, a conus radiatus venom peptide belonging to the neurophysin family
Toxicon Volume 40
Jimenez, E.C., Donevan, S., Walker, C., Zhou, L.M., Nielsen, J., Cruz, L.J., Armstrong, H., White, H.S., Olivera, B.M., (2002) Conantokin-L, a new NMDA receptor antagonist: determinants for anticonvulsant potency
Epilepsy Research Volume 51
Cruz, L.J., Olivera, B.M. , (1986) Calcium channel antagonists. ro-Conotoxin defines a new high affinity site
Journal of Biological Chemistry Volume 261
McLaren, l.,Ngo, D.T.C., Olivera, B.M., (1973) Pyridine nucleotide metabolism in Escherichia coli. III. Biosynthesis from alternative precursors in vivo
Journal of Biological Chemistry Volume 248
Lundquist R., Manlapaz-Fernaddez, P.,Olivera, B.M., (1974) A specific clTect of deoxycytidine 5'-triphosphate on DNA chain initiation in vitro
Journal of Molecular Biology Volume 83
Olivera, B.M., BonhoeITer, F., (1974) Replication of Escherichia coli requires DNA polymerase
Nature Volume 250
Rechsteiner, M., Hillyard, D.,Olivera, B.M. , (1976) Turnover ofNAD in cultures of human cells
Cell. Phys. Volume 88
Olivera, B.M., Lehman, I.R., (1968) Enzymatic joining of polynucleotides, Ill. The polydeoxyadenylate: polydeoxythymidylate homopolymer pair
Journal of Molecular Biology Volume 36
Cruz, L.J., Salabao, J.L., Flores, E. Olivera, B.M., (1975) Pyridine nucleotide metabolism: purification of a nicotinamide mononucleotide-specific deaminase
Kimika Volume 1
Rechsteiner, M., Hillyard, D. and Olivera, B.M., (1975) Turnover of nicotinamide adenine dinucleotide in cultures of human cells
Journal of Cell Physiology Volume 88
Ohlenbusch, RH., Olivera, B.M., Tuan, D. and Davidson, N., (1967) Selective dissociation of histones from calf thymus nucleoprotein
Journal of Molecular Biology Volume 25
Olivera, B.M., Baine, P., Davidson, N. , (1964) Electrophoresis of the nucleic acids
Biopolymers Volume 1
Keyes, T. W.,Olivera, B.M.,Stewart, D.J.and Hanly, E. W. , (1976) Pyridine nucleotide metabolism in imaginal discs of Drosophila melanogaster
Biochem. Gen. Volume 14
Rechsteiner, M.,Hillyard, D., Olivera, B.M. , (1976) Magnitude and significance of NAD turnover in human cell line D9.8/ AH2
Nature Volume 259
Manlapaz-Fernandez. P., Olivera, B.M. , (1973) Pyridine nucleotide metabolism in Escherichia coli. IV. Turnover
Journal of Biological Chemistry Volume 248
Lundquist, R., Olivera, B.M., (1971) DNA synthesis in Escherichia coli in the presence of cyanide
J. Mol. Bioi. 57:263-77 Volume 246
Cruz, L.J., Corpuz, G., Olivera, B.M., (1976) A preliminary study of COl1l1S venom protein.
771e Veliger Volume 18
Olivera, B.M., Hall, Z., Anraku, Y., Chien, I.R., Lehman, I.R. , (1968) On the mechanism ofthe polynucleotide joining reaction
Cold Spring Harbor Symp. Quant. Bioi. Volume 33
Olivera, B.M, Scheider, I.E., Lehman, I.R., (1968) Enzymatic joining of polynucleotides, IV. Formation of a circular deoxyadenylate: Deoxythymidylate copolymer
Journal of Molecular Biology Volume 36
Olivera, B.M., Mcintosh, J.M., Clark, C., Middlemas, D., Gray, W.R., Cruz, L.J. , (1985) A sleep-inducing peptide from C. geographus venom
Toxicon Volume 23
Cruz, L.J.,Gray, W.R. Yoshikami D.and Olivera, B.M., (1985) Conus venoms: A rich source of neuroactine peptides
J. Toxicol.-Toxin Revs. Volume 4
Cruz, L.J., Gray, W.R., Olivera, B.M. , (1978) Purification and properties of a myotoxin from Conus geographus venom
Arch. Biochem. Biophys. Volume 190
Cruz, L.J., Corpuz, G., Olivera, B.M. , (1978) Mating, spawning, development and feeding habits of Conus geographus in captivity
The Nautilus Volume 92
Olivera, B.M., Manlapaz-Ramos, P., Warner, H.R., Duncan, B.K. , (1979) DNA intermediates at the E. coli replication fork. II. Studies on a lllutant in uracil DNA glycosidase
Molecular Biology Volume 128
Rechsteiner, M.,Lund, K., Hillyard, D., Olivera, B.M. , (1974) Autoradiographic studies of pyridine nucleotide metabolism in human culture cells
Cell. Phys. Volume 83
Wang, l.C., Baumgarten, D., Olivera, B.M. , (1967) On the origin of tertiary turns in covalently closed double-stranded cyclic DNA
National Academy of Science, USA Volume 58
Thomas, K.R and B.M. Olivera (1978), (1978) Processivity of DNA exonucleases. Olivera, B.M. (1978) DNA intermediates at the E. coli replication fork: tITect of dUTP. Proc. Nat. Acad. Sci. USA 75:238-42
BioI. Chem. 253:424-29.
Cruz, L.J., Reyes, A., Corpuz, G., Tecson, E.M., Oliera, B.M., (1975) A study of C011llS venom proteins
NRCP Research Bulletin Volume 31
Schwimmer, S., Olivera, B.M., (1966) Electrophoretic properties of enzymically synthesized DNA
Journal of Molecular Biology Volume 20
Cruz, L.J., Gray, W.R., Olivera, B.M., Zeikus,R.D., Kerr, L., D. Yoshikallli, D., Moczydlowski, E., (1985) Conus geograplllls toxins that discriminate between neuronal and muscle sodium channels
Journal of Biological Chemistry Volume 260
Cruz, L.J., Gray, W.R., D. Yoshikami, D., Olivera, B.M., (1985) Conus venoms: A rich source of neuroactive peptides
Journal of Toxicology, Toxin Revs. Volume 4
Olivera, B.M., Gray, W.R., Zeikus, R., Mcintosh,I.M. 1. Varga, I. Rivier, I., V. de Santos, V., Cruz, L.J. , (1985) Peptide neurotoxins from fish-hunting cone snails
Science Volume 230
Olivera, B. M., Mcintosh, J. M., Clark, C., Middlemas, D., Gray, W. R., Cruz, L. J., (1985) A sleep-inducing peptide from C. geographus venom
Toxicon Volume 23:
Cruz, L.J., Olivera, B.M., (1986) Calcium channel antagonists. ro-Conotoxin defines a new high affinity site.
Journal of Biological Chemistry Volume 261
Olivera, B.M., Lehman, I.R., (1967) Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.
National Academy of Science, USA. Volume 57
Olivera, B.M., Lehman, I.R. , (1967) Diphosphopyridine nucleotide: a cofactor for the polynucleotide joining enzyme from Escherichia coli
National Academy of Science, USA Volume 57
Olivera, B.M., Bonhoeffer, F. , (1972) Replication of oX174 DNA by Escherichia coli PoIA- in vitro
Proc.,National Academy of Science, USA Volume 69
Woodward, S.R., Cruz, L.J., Olivera, B.M., Hillyard, D.R., (1990) Constant and hypervariable regions in conotoxin propeptides.
EMBO Volume 1(1)
Ferro, A.M., Higgins, N.P., Olivera, B.M., (1983) Poly(ADP-ribosylation) of a DNA topoisomerase.
Journal of Biological Chemistry Volume 258
Gray, W.R., Rivier, D.R. Galyean, R., Cruz, L.J., Olivera, B.M., (1983) Tonotoxin MI: Disulfide bonding and conformational states
Journal of Biological Chemistry Volume 258
Higgins, N.P., Manlapaz-Ramos, P., Gandhi, R.T.,Olivera, B.M., (1983) Bacteriophage Mu: A transposing reflicon
Cell Volume 33
Higgins, N.P.,Moncecchi, D.,Manlapaz-Ramos, P.,Olivera, B.M., (1983) Mu DNA replication in vitro
Journal of Biological Chemistry Volume 258
Higgins, N.P., Howe, M.M., Moncecchi, D., Manlapaz-Ramos, P., Olivera, B.M., (1983) Replicative trnsposition of bacteriophage Mu in vitro.
New York
Hughes, K.T., Cookson, B.T., Ladika, D., Olivera, B.M., (1983) 6-aminonicotinamide resistant mutants of Salmonella typhimurium
Journal of Bacteriology Volume 154
Hudges, K.T.,Ladhika, D.,Roth, J.R., Olivera, B.M., (1983) An indespensable gene for NAD biosynthesis in S. typhimurium
Journal of Bacteriology Volume 155
Wagner, J.A., Guggino, S.E. Reynolds, I.J. Snowman, A.M. Biswas, A. Olivera, B.M. Synder, S.H., (1988) Calium antagonist receptors. Clinical and physiological relevance
Ann. N.Y. Acad. Sci. Volume 552
Huang, R. C. and Davidson, N., (1965) Elektrophoretische Untersuchungen an Nukleoshistone
Ber. Bunsenges, Physik. Chem. Volume 68
Schwimmer, S. and Olivera, B.M., (1966) Electrophoresis of products of DNA- and nucleohistone-supported DNA synthesis
Biopolymers
Ohlenbusch, RH., Olivera, B.M., Tuan, D. and Davidson, N. , (1967) Selective dissociation of histones from calfthymus nucleoprotein
J. Mol. Biol.
Olivera, B.M. and Lehman, I.R., (1967) Linkage of polynucleotides through phosphodiester bonds by an enzyme from Escherichia coli.
Proc. Natl. Acad. Sci. USA
Olivera, B.M. and Lehman I. R., (1967) Diphosphopyridine nucleotide: a cofactor for the polynucleotide joining enzyme from Escherichia Coli.
Proc. Nat. Acad. Sci., USA
Olivera, B.M. and Lehman, I. R., (1968) Enzymatic joining of polynucleotides, III. The polydeoxyadenylate: polydeoxythymidylate homopolymer pair
J. Mol. Biol.
Olivera, B.M., Hall, Z. and I.R. Lehman, I. R., (1968) Enzymatic joining of polynucleotides, DNA-adenylate intermediaLe in the polynucleotide-joining reaction
Proc. Natl. Acad. Sci., USA Volume 61
Olivera, B.M., Hall, Z., Anraku, Y., Chien, I. R. and Lehman, I.R., (1968) On the mechanism ofthe polynucleotide joining reaction
Cold Spring Harbor Symp. Quant. Biol. Volume 33
Laipis, P. J., Olivera, B. M. and Ganesan, A. T. , (1969) Enzymatic cleavage and repair of transforming DNA
Proc. Natl. Acad. Sci., USA Volume 62
Olivera, B.M. and Lundquist, R., (1971) DNA synthesis in Escherichia coli in the presence of cyanide
J. Mol. Biol. Volume 57
Lundquist, R. Olivera, B.M., (1971) Pyridine nucleotide metabolism in Echerichia coli. I. Exponential growth
J. Biol. Chem. Volume 246
Olivera, B. M. and Bonhoeffer, F., (1972) Replication of 4>X174 DNA, Escherichia coli. Pola- in vitro
Proc. Natl. Acad. Sci., USA Volume 69
Olivera, B.M. and Bonhoeffer, F., (1972) Discontinuous DNA replication in vitro
Nat. New Biol. Volume 240
Olivera, B.M., K.G. Lark, K. G., Hermann, R. and Bonhoeffer, F., (1973) Discontinuous DNA synthesis in vitro: A method for defining the role off actors in replication in DNA synthesis in vitro
In: RD. Wells and RB. Inman (eds.), University Park Press, Baltimore
Hillyard, D., M.C. Rechsteiner and B.M. Olivera.,, (1973) Pyridine nucleotide metabolism in mammalian cells in culture.,
J. Cell Phys., Volume 82
Lundquist, Rand B.M. Olivera.,, (1973) Pyridine nucleotide metabolism in Escherichia coli.,
J. Bioi. Chem., Volume 248
McLaren, l, D.T.C. Ngo and B.M. Olivera.,, (1973) Pyridine nucleotide metabolism in Escherichia coli.,
Biosynthesis from alternative precursors in vivo. J. Biol Chem., Volume 248
Manlapaz-Fernandez. P. and Olivera, B.M. , (1973) pyridine nucleotide meabolism in Escherichia coli. IV.
Turnover. 1. Biol Chem., Volume 248
Olivera, B.M. and F. Bonhoeiter, F., (1974) Replication of Escherichia coli requires DNA polymerase
Nature Volume 250
Rechsteiner, M., K. Lund, D. Hillyard and B.M. Olivera.,, (1974) Autoradiographic studies of pyridine nucleotide metabolism in human culture cells.,
Cell. Phys., Volume 83
(1975) A study of C011llS venom proteins. NRCP Res. Bull.,
Cruz, L.1., A Reyes, G. Corpuz, E.M. Tecson and B.M. Olivera., Volume 31
Cruz, L.J., J.L. Salabao, E. Flores and B.M. Olivera.,, (1975) Pyridine nucleotide metabolism: purification of a nicotinamide mononucleotide-specific deaminase.,
Kimika., Volume 1
Rechsteiner, M., Hillyard, D. and Olivera,B.M., (1975) Turnover of nicotinamide adenine dinucleotide in cultures of human cells
J. Cell Physiology Volume 88
Cruz, L.J., G. Corpuz and B.M. Olivera.,, (1976) A preliminary study of Conus venom protein.,
The Veliger., Volume 18
Keyes, T. W., B.M. Olivera, D.J. Stewart and E. W. Hanly.,, (1976) Pyridine nucleotide metabolism in imaginal discs of Drosophila melanogaster., '
Biochem. Gen., Volume 14
Rechsteiner, M., D. Hillyard and B.M. Olivera.,, (1976) Magnitude and significance of NAD turnover in human cell line.,
D9.8/ AH2. Nature., Volume 259
Rechsteiner, M., D. Hillyard and B.M. Olivera., , (1976 ) Turnover of NAD in cultures of human cells.,
Cell. Phys., Volume 88
Cruz, L.J., Corpuz, G. and B.M. Olivera, B.M., (1978) Mating, spawning, development and feeding habits of Conus geographus in captivity
The Nautilus Volume 92
Cruz, L.J., Gray, W.R. and Olivera, B.M., (1978) Purification and properties of a myotoxin from Conus geographus venom.,
Arch. Biochem. Biophys., Volume 190
(1978) Thomas, K.R and B.M. Olivera., Processivity of DNA exonucleases.,
Biol. Chem., Volume 253
(1978) Olivera, B.M., DNA intermediates at the E. coli replication fork., effect of dUTP.,
Proc. Nat. Acad. Sci. USA., Volume 75
Olivera, B.M., P. Manlapaz-Ramos, H.R Warner and B.K. Duncan.,, (1979) DNA intermediates at the E. coli replication fork., Studies on a lllutant in uracil DNA glycosidase.,
Mol. Biol., Volume 128
Thomas, K.R., Manlapaz-Ramos, P. Lundquist, R. and Olivera, B.M., (1979) Formation of Okazaki pieces at the E. coli replication fork in vitro
Cold Spring Harbor S:vmp. Quant. Biol Volume 43
Manser, T., Olivera, B.M. and Haugli, F.B., (1980) NAD turnover in microplasmodia of Physarum polycephalum
Cell Phys. Volume 102
Olivera, B.M., M.C. Rechsteiner, P. Manlapaz-Ramos, L.J. Cruz and D. Hillyard,M. Smulson and T. Sugimura ., , (1980) ADP ribosylation and the pyridine nucleotide cycle.,
Elsevier North Holland.,
Clark, C., B.M. Olivera and L.J. Cruz.,, (1981) A toxin from Conus geogrqphus venom which acts on the vertebrate central nervous system.,
Toxicon
Gray, W.R, Luque, A., Olivera, B.M., Barrett and Cruz, L. J., (1981) Peptide toxins from Conus geographus venom
J. Biol. Chem. Volume 256
Hillyard, D., Rechsteiner, M., Ramos, P.M., J.S. Imperial, J. S., Cruz, L. J. and Olivera, B.M., (1981) The pyridine nucleotide cycle, studies in E. coli and the human cell line
Biol. Chem. Volume 256
Ferro, AM. and B.M. Olivera.,, (1982) Poly (ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism.
Biol Chem., Volume 257
G.P., Liu, J. Foster, J., Manlapaz-Ramos, P. and B.M. Olivera, B. M., (1982) Nucleoside salvage pathway for NAD biosynthesis in Salmonella typhii
Bact. Volume 152
Lundquist, R. C. and Olivera, B.M. , (1982) Transient generation of displayed single-stranded DNA during nick translation
Cell Volume 91
Mcintosh, M., Cruz, L.J., Hunkapiller, M.W., Gray, W.R and Olivera, B.M. , () Isolation and structure of a peptide toxin from the marine snail Conus magus
Arch. Biochem. Biophys. Volume 218
Olivera, B.M. and AM. Ferro, O.Hayaishi and K. Ueda ., , (1982) Pyridine nucleotide metabolism and ADP ribosylation. In: ADP-Ribosylation Reactions.,
Academic Press, New York.,
Ferro, AM., Higgins, N.P. and Olivera, B.M., (1983) Poly(ADP-ribosylatibn) of a DNA topoisomerase.,
J. Biol. Chem., Volume 258
(1983) Gray, W.R., J.E. Rivier, R Galyean, L.J. Cruz and B.M. Olivera., tonotoxin MI: Disulfide bonding and conformational states.,
Biol. Chem., Volume 258
Higgins, N.P., Manlapaz-Ramos, P. Gandhi, RT. and Olivera, B.M., (1983) Bacteriophage Mu: A transposing replicon
Cell Volume 33
Higgins, N.P., D. Moncecchi, P. Manlapaz-Ramos and B.M. Olivera.,, (1983) Mu DNA replication in vitro.,
J. Biol. Chem., Volume 258
Higgins, N.P., D. Moncecchi, M.M. Howe, P. Manlapaz-Ramos and B.M. Olivera.,, (1983) Replicative transposition of bacteriophage Mu in vitro. In: Mechanisms of DNA Replication and Recombination,
Alan R Liss, New York.,
Hughes, K.T., B.T. Cookson, D. Ladika, B.M. Olivera and J.R Roth., , (1983) 6-aminonicotinamide resistant mutants of Salmonella typhimurium.,
J. Bact., Volume 154
Hughes, K.T., D. Ladika, JR Roth and B.M. Olivera.,, (1983) An indispensable gene for NAD biosynthesis.,
J. Bact., Volume 155
Jimenez, E.C., Olivera, B.M. and Cruz, L.J., (1983) Localization of enzymes and possible toxin precusors in granules from CO/IUS striatus venom.,
Toxicon Suppl., Volume 3
Thomas, K.R and B.M. Olivera.,, (1983) Flexibility in RNA priming of Okazaki pieces at the E. coli replication fork.,
Nucleic Acids Res., Volume 11
Ferro, AM., L.H. Thompson and B.M.Olivera, U. Hubscher and S. Spadari.,, (1984) Poly(ADP-ribosylation) and DNA topoisomerase in different cell lines; In: Proteins Involved in DNA Replication.,
Plenum Publishing Corp.,
Cruz, L. J., Gray, W. R., Olivera, B. M., Zeikus, R. D., Kerr, L., Yoshikami, D. and Moczydlowski, E., (1985) Conus geograplllls toxins that discriminate between neuronal and muscle sodium channels
J. Biol. Chem. Volume 260
Cruz, L.J., Gray, W.R., Yoshikami, D. and Olivera, B.M., (1985) Conus vcnoms: A rich source of neuroactive peptides.,
J. Toxicol Toxin Revs., Volume 4
Gray, W.R., Middlemas, D.M., Zeikus, R., Olivera, B.M., Cruz, L.I., Deber, C.M., Hruby, V.I. and Kopple, K.D., (1985) Structure-activity relationships in a-conotoxins: a model. In: Peptides: Structure and Function.,
The Ninth American Peptide Symposimn, Pierce Chemicals Pubs.,
Olivera, B.M., Gray, W.R. Zeikus, R 1.M. Mcintosh, 1. Varga. l Rivier. V. de Santos and Cruz, LJ, (1985) Peptide neurotoxins from fish-hunting cone snails
Science Volume 230
Olivera, B.M., J.M. Mcintosh, C. Clark, D. Middlemas, W.R Gray and LJ. Cruz., , (1985) A sleep-inducing peptide from C. geographus venom.,
Toxicon., Volume 23
Cruz, L. and Olivera, B.M., (1986) Calciwn channel antagonists. ro-Conotoxin defines a new high affinity site
J. Biol. Chem. Volume 261
Ferro, A.M. and Olivera, B.M., (1986) Intracellular pyridine nucleotide degradation and turnover.,
Coenzymes and Cofactors.,
Malapaz-Fernandez, P., Olivera, B.M., () Pyridine nucleotide metabolism in Escherichia Coli
Journal Biological Chemistry
Lundquist R. P. Manlapaz-Fernandez and BM. Olivera, (1974) A specific effect od deoxytidine 5`-triphosphayte on DNA chain iniation in vitro.
J.Mol.Biol
Olivera.B.M and F.Bonhoeffer, (1974) Replication of eschericha coli requires DNA polymerase.
Nature
Rechsteiner,M., K Lund, D. Hillyard and B.M. Olivera., (1974) Autogradiographic studies of pyridine nucleotide metabolism in human cells.
J.Cells Phys.
Cruz, L.J., A. Reyes, G.Corpuz, E.M. Tecson and B.M. Olivera, (1975) A Study of Conus venom proteins.
NRCP Res. Bull
Cruz, L.J., Salabao, J.L., Flores, E. and Olivera, B.M., (1975) Pyridine nucleotide metabolism: purification of a nicotinamide mononucleotide-specific deaminase
Kimika Volume 1
Rechsteiner, M., D. Hillyard and B. Olivera , (1975) Turnover of nicotinamide adenine dinucleotide in cultures of human cells.
J. Cell. Physiol Volume 88
Cruz, L.J., G. Corpuz and B.M. OLivera, (1976) A preliminary study of Comus venom protein.
The Veliger Volume 18
Keyes, T.W., B.M. Olivera, D.J. Stewart and E.W. Hanly , (1976) Pyridine nucleotide metabolism in imaginal disc of Drosophila melanogaster.
Biochem. Gen. Volume 14
Rechsteiner, M., D. Hillyard and B.M. Olivera , (1976) Magnitude and significance of NAD turnover in human cell line D98/AH2.
Nature Volume 259
Rechsteiner, M., Hillyard, D. and Olivera, B.M., (1976) Turnover of NAD in cultures of human cells
J. Cell. Phys. Volume 88
Cruz, L.J.,Corpuz, G. and Olivera, B.M., (1978) Mating, spawing, development and feeding habits of Conus geographus in captivity
The Nautilus Volume 92
Cruz, L.J., Gray, W.R. and Olivera, B.M., (1978) Purification and properties of a myotoin form Conus geographus venom
Arch. Biochem. Biophys. Volume 190
Thomas, K.R. and Olivera, B.M., (1978) Processivity of DNA exonucleases
J. Biol. Chem. Volume 253
Olivera, B.M., (1978) DNA intermediates at the E. coli trepliaction fork: effect of dUTP
Proc. Nat. Acad. Sci. USA Volume 75
Olivera, B.M., Manlapaz-Ramos, P. Warner, H.R. and Duncan, B.K. , (1979) DNA intermediates at the E. coli replication fork. II. Studies on a mutant in uracil Dna glycosidase
J. Mol. Biol. Volume 128
Olivera, B.M., (1979) Formation of Okazaki pieces at the E. coli replication fork in vitro
Cold Spring Harbor Symp. Quant. Biol. Volume 43
Manser, T., olivera, B.M. and Haugli, F.B., (1980) NAD turnover in microplasmodia of Physarum polycaphalum
J. Cell Phys. Volume 102
Olivera, B.M., M.C. Rechsteiner, P. Manlapaz-Ramoz, L.J. Cruz, D. Hillyard, (1980) ADP-ribosylation and the pyridine nucleotide cycle. In: Proceeedings of the Conference of Novel ADP-ribosylation of Regaulatory Enzymes and Proteins, M. Smulson and T. Sugimura
Elsevier North Holland
Clark, C., Olivera, B.M. and Cruz, L.J., (1981) A toxin from Conus geographs venom which acts on the vertebrate central nervous system
Toxicon Volume 19
Gray, W.R., Luque, A.,Olivera, B.M. Barrett, and Cruz, J., (1981) Peptide toxins from Conus geographus venom
J. Biol. Chem. Volume 256
Hillyard, D., Rechstenier, M.P. Ramos, M. Imperial, J.S. Cruz, L.J. and Olivera, B.M., (1981) The pyredine nucleotide cycle. Studiesn E. coli and the human cell line D98/AH2
J. Biol. Chem. Volume 256
Ferro, A.M. and Olivera, B.M., (1982) Poly (ADP-ribosylation) in vitro. Reaction parameters and enzyme mechanism
J. Biol. Chem. Volume 257
Liu, G.P., Foster, J. Manlapaz-Ramos M. and Olivera, B.M. , (1982) Nucleoside salvage pathway for NAD biosynthesis in Salmonella typhimurium
J. Bact. Volume 152
Lundquist, R.C. nad Olivera, B.M., (1982) Transcient generation of displaced single-stranded DNA during nick translation
Cell Volume 31
Mclntosh, M., Cruz, L.J. Hunkapiller, M.W. Gray, W.R. and Olivera, B.M., (1982) Isolation and structure of a peptide toxin from the marine sanil Conus magus
Arch. biochem. Biophys. Volume 218
Olivera, B.M. and A.M. ferro, (1982) Pyridine nucleotide metabolism and ADP-ribolsylation.
Academic Press, New York
Ferro, A.M., McElwain, M.C. and Olivera, B.M., (1984) Poly(ADP-ribosylation) of DNA topoisomerase I: a nuclear response to DNA-strand interruptions
Cold Spring Harbor Symp. Quant. Biol. Volume 49
Ferro, A.M., Hinggins,N.P. and Olivera, B.M. , (1983) Poly(ADP-ribosylation)of a DNA topoisomerase
J. Biol. Chem. Volume 258
Gray, W.R., Rivier, J.E. Galyean, R. Cruz, L.J.and Olivera, B.M., (1983) Conotoxin MI: Disulfide bonding and conformational states
J. Biol. Chem. Volume 258
Hinggins, N.P., Manlapaz-Ramos, P. Gandhi, and Olivera, B.M., (1983) Bacteriophage Mu: a transposing replicom
Cell Volume 33
Hinggins, N.P., Moncecchi, D. Manlapaz-Ramos P. and Olivera, B.M., (1983) Mu DNA replication in vitro
J. Biol. Chem. Volume 258
Hinggins, N.P., D. Monecchi, M.M. Howe, P. Manlapaz-Ramos and B.M. Olivera, (1983) Replicative transposition of bacteriophage Mu in vitro.
In: Mechanisms of Dna replication and Recombination, Alan R. Liss, New York
Hughes, K.T., B.T. Cookson, D. Ladika, B.M. Olivera and J.R. Roth, (1983) 6-aminonicotinamide resistant mutants of Salmonella typhimurium.
J. Bact. Volume 154
Hughes, K.T., Ladika, D. Roth, J.R. and Olivera, B.M., (1983) An indispensable gene for NAD biosynthesis in S. typhimurium
J. Bact Volume 155
Jimenez, E.C., Olivera, B.M. and Cruz, L.J., (1983) Localization of enzymes and possible toxin precusors in granuales from Conus striatus venom
Toxicon Suppl. Volume 3
Thomas, K.R. and Olivera, B.M., (1983) Flexibilty in RNA printing of Okazaki pices at the E. coli replication fork
Nucleic Acids Res. Volume 11
Ferro, A.M., L.H. Thompson and B.M. Olivera , (1984) Poly(ADP-ribosylation) and DNA topoisomerase I in different cell lines.
Plenum Publishing Corp.,
Ferro, A.M. and Olivera, B.M., (1984) Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus
J. Biol. Chem. Volume 259
Gray, W.R., Luque, F.A. Galyaen, R., Atherton, E., Sheppard, R.C., Stone, B.L., Reyes, A., Alford, J., Mclntosh, M., Olivera, B.M., Cruz, L.J.and Rivier, J., (1984) Conotoxin GI: Disulfide brdges, synthesis and preparation of iodinated derivatives
Biochemistry Volume 23
Higgins, N.P. and Olivera, B.M., (1984) Criteria for initiation
Mol. Gen. Gene Volume 194
Higgins, N.P., P. Manlapaz-ramos and B.M. Olivera, (1984) Analysis of Mu DNA replicated on cellophane discs.
Plenum Publishing Corp.
Jeter, R.M., Olivera B.M and Roth, J.R., (1984) S.typhimurium synthesizes cobalamin (Vitamin B12) de novo under anaerobicgrowth conditions
J. Bact. Volume 159
Olivera, B.M., McIntosh, J.M. Cruz, L.J. Luque, F.A. and Gray, W.R., (1984) Purification and sequence of a presynaptic peptide toxin from C. geographus venom
Biochemistry Volume 23
Cruz, L.J.,Gray, W.R. Olivera, B.M. Zeikus,R.D. Kerr, L. Yoshikami, D.and MoczyDlowski, E., (1984) Conus geograhus toxins that discriminate between neuronal and muscle sodium channels.
J. Biol. Chem. Volume 260
Gray, W.R., Middlemas, D.M., Zeikus, R., Olivera, B.M., Cruz, L.J., () Structure-activity relationships on α-conotoxins: a model. In: Peptides: Structure and Function
The Ninth American Paetide Symposium, Pierce Chemicals Pubs
Olivera, B.M., Gray, W.R., zeikus, R., McIntosh, J.M., Varga, J., Rivier, J., de Santos, V. Cruz, L.J. , (1985) Peptide neurotoxins from fish-hunting cone snails
Science Volume 230
Olivera, B.M., J.M. McIntosh, C.Clark D. Middlemas, Gray, Cruz, L.J., (1985) A sleep-including peptide from C. geogrpus venom
Toxicon Volume 23
Cruz, L.J., Olivera, B.M., (1986) Calcium channel antagonists. -Conotoxins defines a new high affinity site
J. Biol. Chem. Volume 261
Ferro, A.M., Olivera, B.M. , () Intracellular pyridine nucleotide degradation and turnover
In: Coenyzmes and Cofactors, John and Wiley and Sons
Moczydlowski, E.,Olivera, B.M., Gray, W.R. Strichartz, G.R., (1986) Discrimination of muscle and neuronal Na-channle subtypes by binding competotion between [3H]saxitoxin and -conotoxin
Proc. Natl. Acad. Sci. Volume 83
Reynolds, I.J., Wagner, J.A. Synder, S.A. Thayer, S.M.Olivera, B.M. Miller, R.J. , (1986) Brain-voltage-sensitive calcium channel subtypes differentiated by -conotoxin fraction GVIA
Proc. nat. Acad. Sxi. Usa Volume 83
Reymolds, I.J., Wagner, J.A. Synder, S.A. Thayer, S.M. Olivera, B.M. Milller, R.J., (1986) Brain voltage-sensitive calcium channel subtypes differentiated by -conotoxin fraction GVIA
Proc. Nat. Acad. Sci. USA Volume 83
Cookson, B.T., Olivera, B.M., (1987) Genetic characterization and regulatin of the nadB locus of Salmonella typhimurium
J. Bact. Volume 169
Cruz, L.J., LeCheminant, G.W. and Olivera, B.M., (1987) Characterization of the -conotoxin target. Evidence fro tissue-specific heterogeneity in calcium channel types
Biochemistry Volume 26
Cruz, L.J., G.W. LeCheminant, Olivera, B.M. , () Biochemical studies of ω-conotoxin GVIA, a peptide toxin inhibiting voltage sensitive Ca channels
In: Integration and control of Metabolic Processes, Cambridge University Press
Cruz, L.J., de Santos,V. Zafaralla, G.C. Ramillo, C.A. Zeikus, R. Gray, W.R. Olivera, B.M., (1987) Invertebate vasopressin/oxytocin homologs. Characterization of peptides from Conus striatus venoms
J. Biol. Chemistry Volume 262
Feldman, D.H., Olivera, B.M., Yoshikami, D., (1987) Omega-Conus geographus toxin: a peptide that blocks calcium channels
FEBS Lett Volume 214
Hughes, K.T., Olivera, B.M., Roth, J.R., (1987) Rec depandence of Mu transposition from P22-transduced fragments
J. Bact. Volume 169
Jeter, R., Escalante-Semerena, J.C., Roof, D., Olivera, B.M., Roth, J., (1987) Synthesis and use of Vitamin B12 in Escherichia coli and Salmonella typhimurium. In: Cellular and Molecular Biology
ASM, Wshington, D.C
(1987) Calcium channel blockade by a peptide from Conus: Specificity and mechanism
Proc. Nat. Acad. Sci. USA Volume 84
McCleskey, E.W., Fox, A.P. Feldman, D. Cruz, L.J. Olivera, B.M. Tsien, R.W. Yoshikami, D., (1987) Calcium channel blockade by a peptide from Conus: Specificity and mechanism
Proc. Nat. Acad. Sci. USA Volume 84
Olivera, B.M., Cruz, L.J., de Santos, V. LeCheminant, G. Griffin, D. Zeikus, R. McIntosh, J.M. Galyean, R. Varga, J. Gray, W.R. Rivier, J., (1987) Neuronal Ca channel antagonists. Discrimination between Ca channel subtypes using ω-conotoxin from Conus magus venom
Biochemistry Volume 26
Rivier, J., Galyean, R. Simon, L. Cruz, L.J. Olivera, B.M. Gray, W.R., (1987) Total synthesis and further characterization of the γ-carboxyglutamate-containing "sleeper" peptide from Conus geographus venom
Biochemistry Volume 26
Rivier, J., Galyean, R.,Gray, W.R.,Azimi-Zonooz, A. McIntosh, J.M., Cruz, L.J., Olivera, B.M., (1987) Neuronal calcium channel inhibitors. Synthesis of ω-conotoxin GVIA and effects on 45Ca-uptake by synaptosomes
J. Biol. Chem. Volume 262
Wganer, J.A., Snowman, A.M., Olivera, B.M. Snyder, S.H., (1987) Aminoglycoside effects on voltage-sensitive Ca channels and neurotoxicity
N. Engl. J. Med. Volume 317
DeAizpurua, H.J., Lambert, E.H. Griesmann, G.E. Olivera, B.M. Lennon, J.A., (1988) Antagonism of voltage-gated calcium channels in small cell carcinomas of patints with and without Lambert-Eaton Myasthenis Syndrome by autoantibodies
Cancer Res Volume 48
Gray, W.R., Olivera, B.M., Cruz, L.J., Rivier, J. , (1988) A model for "sleeper peptide"(conotoxin GV) and other Gla-containing molecules. In: Peptide Chemistry
Protein Research Foundation, Osaka
Gray, W.R., Olivera, B.M. Cruz, L.J., (1988) Peptide toxins from venomous Conus snails
Ann. Rev. Biochem. Volume 57
Hirning, L.D., Fox, A.P. McCleskey, E.W. Olivera, B.M. Thayer, S.A. Miller, R.J. Tsein, R.W., (1988) Dominant role of N-type Ca2+ channels in evoked release of norepinephrine form sympathetic neurons
Science Volume 239
(1988) Structural gene for NAD synthetase in Salmonella typhimurium
J. Bact
Hughes, K.T., Olivera, B.M., Roth, J.R., (1988) Structural gene for NAD synthetase in Salmonella typhimurium
Journal of Bacteriolog Volume 120
Kerr, L.M., Filloux, F., Olivera, B.M.,Jackson, H. Walmsley, J.K., (1988) Autoradiographic localization of calcium channels [125]ω-conotoxin in rat brain
Eur. J. Pharmacol Volume 146
Olivera, B.M., W.R. Gray, L.J. Cruz, (1988) Marine snail venoms. In Handbook of Natural Toxins, Vol. 4, Marine Toxins and Venoms
A. Tu (ed.), Marcel Dekker, Inc., New York and Basel
Park, U.E., J.R. Roth, Olivera, B.M., (1988) Salmonella typhimurium mutants lacking NAD pyrophosphatase
J. Bact. Volume 170
Wagner, J.A., Snowman, A.M. Biswas, A. Olivera, B.M. Snyder, S.H., (1988) ω-Conotoxin GVIA binding to a high-affinity receptor in brain: characterization, calcium sensivity, and sobulization
J. Neurosci. Volume 9
Zafaralla, G.C., Ramillo, C. Gray, W.R. Karlstorm, R. Olivera, B.M. , (1988) Phylogenetic specficity of cholinergic ligands: α-conotoxin SI
Biochemistry Volume 27
Zafaralla, G.C., Ramillo, C. Gray, W.R. Karlstorm, R. Olivera, B.M., (1988) Phylogenetic specficity of cholinergic ligands: α-conotoxin SI
Biochemistry Volume 27
Zhu, N.,Olivera, B.M. Roth, J.R., (1988) Identification of a reprosseor gene involved in the regulation of NAD de novo biosynthesis in Salmonella typhimurium
J. Bact. Volume 170
Cruz, L.J., Kupryzewski, G. LeCheminant, G.W. Gray, W.R. Olivera, B.M. Rivier, J., (1988) α-Conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling and receptor characterization
Biochemistry Volume 28
Cruz, L.J., Kupryzewski, G. LeCheminant, G.W. Gray, W.R., Olivera, B.M. Rivier, J. , (1988) μ-Conotoxin GIIIA, a peptide ligand for muscle sodium channels: chemical synthesis, radiolabeling and receptor characterization
Biochemistry Volume 28
Cruz, L.J., Johnson, D.S. Imperial,J.S. Griffin, D. LeCheminant, G.W. Milijanich, G.P.Olivera, B.M. , (1989) ω-Conotoxins and voltage-sensitive calcium channels subtypes
Curr. Top. Memb. transportation Volume 33
Cruz, L.J., Johnson, D.S. Imperial, J.S. Griffin, D. LeCheminant, G.W. Milijanich, G.P. Olivera, B.M., (1989) ω-Conotoxins and voltage-sensitive calcium channels subtypes
Curr. Top. Memb. transp. Volume 33
Hillyard, D.R., Olivera, B.M. Woodward, S. Corpuz, G.P. Gray, W.R. Ramilo, C.A. Cruz, L.J., (1989) A molluscivorous Conus toxin: Conserved frameworks in conotoxins
Biochemistry Volume 28
Olivera, B.M., K.T. Hughes, P. Corday, J.R. Roth, (1989) Aspects of NAD metabolism in prokaryotes and eukaryotes. In ADP-Ribose transfer Reactions. Mechanisms and Biological Sinificance
M.K. jacobson and E.L. Jacobson (eds.), Springer Verlag, New York
Park, U.E., Olivera, B.M. Hughes, K.T. Roth, J.R. Hillyard, D.R., (1989) DNA ligase and the pyridine nucleotide cycle in Salmonella typhimurium
J. Bact. Volume 171
Yoshikami, D., Bagabaldo, Z. Olivera, B.M., (1989) The inhibitory effects of omega-conotoxins on calcium channels and synapses
Ann. N.Y. Acad. Sci. Volume 560
Zhu, N., Olivera, B.M. Roth, J.R., (1989) Genetic characterization of the pnuC gene, which encodes a component of the nicotinamide mononucleotide transport system in Salmonella typhimurium
J. Bact. Volume 171
Fox, AP., Hirning, L.D., Kongsamut, S., McCleskey, E.W., Miller, R.J., Olivera, B.M., Perney, T.M., Thayer, S.M., Tsien, R.W., (1990) The interaction of toxins with Ca channels. In Nuerotoxins and their Pharmaological Implications
Raven Press
Haack, J.A, Rivier, T.N. Parks, E.E. Mena, Cruz, L.J and Olivera, B.M., (1990) Conantokin-T. A γ-carboxyglutamate containing peptide with N-methyl-D-aspartate antagonist activity
J. Biol. Chem. Volume 265
Hernandez, J.-F.,Olivera, B.M. Cruz, LJ. Myers,RA Abbott, J. and Rivier, J., (1990 F 22- Mr 4) Synthesis, characterization and biological activity of conantokin-G
In: UCLA Symposia Conference on Biochemical and Biomedical Engineering Synthetic Peptides: Approaches to Biological Problems, Frisco, C.O
Hernandez, J.-F., B.M. Olivera, LJ. Cruz, RA Myers, J. Abbott and J. Rivier , (1990) Synthesis, characterization and biological activity of conantokin-G. In: UCLA Symposia Conference on Biochemical and Biomedical Engineering Synthetic Peptides: Approaches to Biological Problems, Frisco, CO, February 22-March 4
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Higgins, N.P., A.M. Ferro and B.M. Olivera, (1990) DNA-topoisomerase modification. In: DNA Topology and its Biological Effects, N.R Cozzarrelli and J.C. Wang (eds.), Cold Spring HarborlLaboratory Press
nn
Mena, E.E., Gullak,M.F. Pagnozzi, M.J. Richter, K.E. Rivier, J. Cruz, L.J. and Olivera, B.M., (1990) Conantokin-G: A novel peptide antagonist to the N-methyl-D-aspartate (NMDA) receptor
Neurosci. Lett Volume 118
Myers, R.A., Mcintosh, J.M. Imperial, J. Williams, R.W.Oas, T. Haack, J.A. Hernandez, J.F. Rivier, J.Cruz, L.J. and Olivera, B.M., (1990) Peptides from Conus venoms which affect Ca++ entry into neurons
J. Toxin-Toxin Revs. Volume 9
Olivera, B.M., D.R. Hillyard, J. Rivier, S. Woodward, W.R Gray, G. C9rpuz and L.J. Cruz , (1990) Conotoxins: targeted peptide ligands from snail venoms. In: Marine Toxins: Origins, Structures, and Molecular Pharmacology, S. Hall and G. Strichartz(eds.)
American Chemical Society, Washington, D.C
Olivera, B.M., Rivier, J. Clark, C. Ramilo, C.A. Corpuz, G.P. Abogadie, F.E. Mena, E.E. Woodward, S.R. Hillyard, D.R. and Cruz, L.J., (1990) Diversity of Conus neuropeptides
Science Volume 249
Woodward, S.R, Cruz, L.J. Olivera, B.M. and Hillyard, D.R., (1990) Constant and hypervariable regions in conotoxin propeptides
EMBO J. Volume 1
Hughes, K.T., Roth, J.R. and Olivera, B.M., (1991) A genetic characterization of the nadC gene of Salmonella typhimurium
Genetics Volume 127
Myers, R.A., Zafaralla, G.C. Gray, W.R. Abbott, J. Cruz, L.J. and Olivera, B.M. , (1991) α-Conotoxins, small peptide probes of the nicotinic acetylcholine receptor
Biochemistry Volume 30
Olivera, B.M., Imperial, J.S. Cruz, L.J.Bindokas, V.P. Venema, V.J. and Adams, M.E., (1991) Calcium channel-targeted polypeptide toxins
Ann. N. Y. Acad. Sci Volume 635
Olivera, B.M., Rivier, J. Scott, J.K. Hillyard, D.R. and Cruz, L.J., (1991) Conotoxins
J. Bioi. Chem Volume 266
Zhu, N., Olivera, B.M. and Roth, J.R., (1991) Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium
J. Bact Volume 173
Lev-Ram, V., B.M. Olivera, I.B. Levitan, G.P. Corpus, C.A. Ramilo, D.R. Hillyard and L.J. Cruz, (1991) Molluscan Conus venoms: a source of toxin probes for molluscan neurobiology. In: Molluscan Neurobiologv
Third Symposium on Molluscan Neurobiology, Amsterdam, Netherlands, August 20-24. 1(90), K.S. Kits, H.H. Boer, 1. Joosse (eds.), North-Holland, Amsterdam
Olivera, B.M., Cruz, L. J., Myers, R. A., Hillyard, D. R., Rivier, J. and Scott, J.K., (1992) Conus peptides and biotechnology
In: Neurotox '91: Molecular Basis of Drug and Pesticide Action, I.R. Duce (ed.), Elsevier, Applied Science, London
Olivera, B.M, Johnson, D. S., Azimi-Zoonooz, A. and Cruz, L. J. , (1992) Peptides in the venom of the geography cone, Conus geographus
In: Toxins and Targets, D. Watters. M. Lavin, D. Maguire and J. Pearn (eds.), Harwood Academic Publishers, Chur, Switzerland
Hammerland, L.G., B.M. Olivera and D. Yoshikami, (1992) Conantokin-G selectively inhibits NMDA-induced currents in Xenopus oocytes injected with mouse brain m-RNA
Eur. J. Pharmacol Volume 226
Cruz, L.J., C.A. Ramilo, G.P. Corpuz and B.M. Olivera , (1992) CONUS peptides: phylogenetic range of biological activity
Biol. Bull Volume 183
Hillyard, D.R., Monje, V.D., Mintz, I.M., Bean, B.P., Nadasdi, L., Ramachandran, J. Miljanich, G., Azimi-Zoonooz, A., McIntosh, J.M., Cruz, L.J., Imperial, J.S. and Olivera, B.M. , (1992) A new CONUS peptIde ligand for mammalian presynaptic Ca channels
Neuron Volume 9
Ramilo, C.A., Zafaralla, G.C., Nadasdi, L., Hammerland, L.G., Yoshikami, D., Gray, W.R., Ramachandran, J., Miljanich, G., Olivera, B.M. and Cruz, L.J., (1992) Novel α- and ω-conotoxins from Conus striatus venom
Biochemistry Volume 31
McIntosh, J.M., Adams, M.E., Olivera, B.M. and Filloux, F., (1992) Autoradiographic localization of the binding of calcium channel antagonist, 125I-ω-Aga-IIIA, in rat brain
Brain Res Volume 594
Santos, A.D., Imperial, J.S. Chaudhary, T. Beavis, R.C. Chait, B.T. Hunsperger, J.P. Olivera, B.M. Adams, M.E. and Hillyard, D.R. , (1992) Heterodimeric structure of the spider toxin ω-Aga-IA reveakd by precursor analysis and mass spectrometry
J. Biol. Chem Volume 267
Cruz, L.J., Corpuz, G.P., Ramilo, C.A., Zafaralla, G., Johnson, B., Leitner, T., Yoshikami, D. and Olivera, B.M., (1992 F 2-7) The biological role and pharmacological uses of conotoxins
In: Proceedings of ASOMPS VII, Seventh Asian Symposium on Medicinal Plants, Spices and Other Natural Products, L.J. Cruz, G.P. Concepcion, MiA.s. Mendigo and B.Q. Guevara(eds.) Manila, Philippines
Olivera, B.M., J. Imperial, J. Hunsperger, C. Colledge, R.A. Myers, A.D. Santos, V.D. MOnje and L.J. Cruz , (1992 F 2-7) Conus peptides, a pharmacologically diverse class of marine natural products
Seventh Asian Symposium on Medicinal Plants, Spices and Other Natural Products, Manila, Philippines
Tisa, L.S., Olivera, B.M., Adler, J. , (1993) Inhibition of Escherichia coli chemotaxis by ω-conotoxin, a calcium-ion channel blocker
Journal of Bacteriology Volume 175
Cruz, L.J. and B.M. Olivera, (1993) Conus venom neuropeptides. In: Neurosciellce Year; Supplemellt 3, B. Smith and G. Adelman (eds.)
Birkhauser Publishing, Cambridge, MA
Myers, R.A., L.J. Cruz, J. Rivier and B.M. Olivera, (1993) CONUS peptides as chemical probes for receptors and ion channels
Chem. Rev Volume 93
Olivera, B.M., McIntosh, J.M. and Cruz,L. J., (1993) Conus peptides as tools for the neuroscientist
In: Gene-Brain-Behaviour, Proceedings of the 21st Gottingen Neurobiology Conference, N. Elsner and M. Heisenberg (eds.) Georg Thieme Verlag, Stuttgart, New York
Monje, V.D., Haack, J. Naisbitt, S. Miljanich, G., Ramachandran, L. Nasdasdi, L., Olivera, B. M., Hillyard, D. R. and Gray, W. R., (1993) A new Conus peptide ligand for Ca channel subtypes
Neuropharnacology Volume 32
Haack, J.A., P. Kinser, D. Yoshikami and B.M. Olivera, (1993) Biotinylauted derivatives of ω-conotoxins GVIA and MVIID: probes for neuronal calcium channels
Neuropharmacology Volume 32
Adams, M.E., Myers, R.A., Imperial, J.S., Olivera, B.M., (1993) Toxityping rat brain calcium channels with toxins from spider and cone snail venoms Biochemistry
Biochemistry Volume 32
AIbensi, B.C., Ryujin, K.T. McIntosh, J.M. Olivera, B.M. and Filloux, F.M., (1993) Autoradiographic localization of conotoxin GVIA binding sites in human hippocampus and cerebellum
NeuroReport Volume 4
McIntosh, J.M., Foderaro, T.N. Li, W. Ireland, C.M. and Olivera, B.M. , (1993) Presence of serotonin in the venom of CONUS imperialis
Toxicon Volume 32
Haack, J.A., Parks, T.N. and Olivera, B.M., (1993) Conantokin-G antagonism ofthe NMDA receptor subtype expressed in cultured cerebellar granule cells
Neurosci. Lett Volume 163
Olivera, B.M., G. Miljanich, J. Ramachandran and M.E. Adams, (1994) Calcium channel diversity and neurotransmitter release: The ω-conotoxins and ω-agatoxins
Ann. Rev. Biochem Volume 63
Filloux, F., J. Karras, J.S. Imperial, W.R. Gray and Olivera, B.M., (1994) The distribution of ω-conotoxin MVIICnle-binding sites in rat brain measured by autoradiography
Neurosci. Lett Volume 178
Adams, M.E. and Olivera, B.M., (1994) Neurotoxins: Overview of an emerging research technology
TINS Volume 17
Filloux, F., Schapper, A., Naisbitt, S., Olivera, B.M., McIntosh, J.M., (1994) Complex patterns of [125]ω-conotoxin GVIA binding site expression during postnatal rat brain development
Dev. Brain Res Volume 78
Lev-Ram, V., Olivera, B.M. and Levitan, I.B., (1994) A toxin from the venom of the predator snail Conus textile modulates ionic currents in Aplysia bursting pacemaker neurons
Brain Res Volume 640
McIntosh, J.M., Yoshikami, D. Mahe, E. Nielsen, D.B. Rivier, J.E., Gray, W.R., Olivera, B.M., (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin
Journal of Biological Chemistry Volume 269
McIntosh, J.M., D. Yoshikami, E. Mahe, D.B. Nielsen, J.E. Rivier, W.R. Gray and B.M. Olivera, (1994) A nicotinic acetylcholine receptor ligand of unique specificity, α-conotoxin ImI
J. Bioi. Chem Volume 269
Shon, K.-J., A. Hasson, M.E. Spira, L.J. Cruz, W.R. Gray and B.M. Olivera , (1994) δ-Conotoxin GmVlA, a novel peptide from the venom of Conus gloriamaris
Biochemistry Volume 33
McIntosh, J.M., Ghomashchi, F., Gelb, M.H., Dooley, D.J., Stoehr, S.J., Giordani, A.B., Naisbitt, S.R., Olivera, B.M. , (1995) Conodipine-M, a novel phospholipase A2 isolated from the venom of the marine snail Conus magus
Journal of Biological Chemistry Volume 270
Shon, K., Grilley, M. Marsh, M. Yoshikami, D. Adrienne, A., Hall, R. Kurz, B. Gray, W., Imperial, J. Hillyard, D. and Olivera, B.M. , (1995) Purification, characterization, synthesis and cloning of the lockjaw peptide from Conus purpurascens venom
Biochemistry Volume 34
McIntosh, J.M., Hasson, A. Spira, M.E. Gray, W.R.W. L.i, Marsh, M., Hillyard, D.R. and Olivera, B.M., (1995) A new family of conotoxins that block voltage-gated sodium channels
J. BioI. Chem Volume 270
Hopkins, C., Grilley, M., Miller, C., K. Shon. K., Cruz, L. J., W.R. Gray, W. R., Dyker, L., Rivier, J. E., Yoshikami, D. and Olivera, B. M. , (1995) A new family of Conus peptides targeted to the nicotinic acetylcholine receptor
Biol. Chem. Volume 270
Craig. D.R. Groebe, S.N. Abramson and 1.M. Mcintosh, Martinez, 1.S., B.M. Olivera, W.R. Gray, AG., , (1995) Conotoxin E1, a new nicotinic acetylcholine receptor antagonist with novel selectivity.,
Biochemistry Volume 34
Hasson, A., Shon, K., Olivera B. M. and Spira, M. E., (1995) Alterations o[voltage-activated Na current by a novel conotoxin from the venom of Conus gloriamaris
J. Neurophysiol. Volume 73
Olivera, B.M., Hillyard, D.R., Marsh, M., Yoshikami, O., (1995) Combinatorial peptide libraries in drug design
Biotechnology Volume 13
Olivera, B.M., Imperial, L.S., Yoshikami, O., (1996) In: Guidebook to Protein Toxins and Their Use in Cell Biology
Instituto Ricerche Immunobiologiche Siena
Olivera, B.M., Steel, O.L., (1996 ) In Guidebook to Protein Toxins and Their Use in Cell Biology
Instituto Ricerche Inll11unobiologiche Siena
Olivera, B.M. and McIntosh, J.M., (1996 ) In: Guidebook to protein toxins and their use in cell biology
Instituto Ricerche Immunobiologiche Siena
Cartier, G.E., Yoshikami, D.Y., Gray, W.R., Luo, S., Olivera, B.M., McIntosh, J.M. , (1996 ) A new @conotoxin which targets @B2 nicotinic acetylcholine receptors
Journal of Biological Chemistry Volume 271
Teclau, H., K. Shon. M. Grilley, M. Stocker. W. Stiihmer and B.M. Olivera.,, (1996) Strategy for rapid immobilization of prey by a fish-hunting cone snail.,
Nature., Volume 381
Wilson, G.F., F.C. Richardson, T.E. Fisher, B.M. Olivera and L.K. Kaczmarek., , (1996) Identification and characterization of a Ca2+-sensitive nonspecific cation channel underlying prolonged repetitive firing in Aplysia neurons.,
Neurosci Volume 16
Mitchell, S.S., K. Shon, B. Olivera and C.M. Ireland.,, (1996) NMR structures of conotoxins.,
J. Nat. Toxins Volume 5
Terlau, H., M. Stocker, K. Shon, 1.M. McIntosh and B.M. Olivera., , (1996) Conotoxin MrVIA inhibits mammalian sodium channels but not through site.,
Neurophysiol Volume 76
Jimenez, E.C., Olivera, B.M., Gray, W.R. and Cruz, L. L., (1996) Contryphan. a D-tryptophan-containing Conus peptide.,
J. Biol. Chem., Volume 281
Albillos, A, AG. Garcia, B. Olivera and L. Gandia.,, (1996) Re-evaluation of the P/Q Ca2+ channel components of Ba2+ currents in bovine chromaffin cells superfused with solutions containing low and high Ba2+ concentrations.,
Plagers Arch. Eur. J. Physiol., Volume 432
Tabata, T., Olivera, B.M., Ishida, A.T., (1996) Conotoxin MVIID blocks an ro-conotoxin GVIA sensitive high-threshold Ca2+ current in fish retinal ganglion cells
Neuropharmacology Volume 35
Gandia, L., B. Lara, Imperial, I.S., Villarroya, M., Albillos, A., Maroto, R., Garcia A. G. and Olivera, B. M., ( 1997) Analogies and differences between ro-conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells
Pflugers Arch. Volume 435
Han, K., Hwang, K., Kim, S.M., Kim, S. K., W. Gray, W., Olivera, B. M., Rivier, J. and K. Shon, K., (1997) NMR structure determination of a novel conotoxin
Biochemistry Volume 36
Kulak, J.M., Nguyen, T.A., Olivera, B.M., Mcintosh, J.M., (1997) Conotoxin MII blocks nicotine-stimulated dopamine release in rat striatal synaptosomes
Journal of Neuroscience Volume 17
Stanley, T.B., Stafford, D. W., Olivera, B.M. and Bandyopadhyay, P. K., (1997) Identification of a vitamin K-dependent carboxylase in the venom duct of a Conus snail
FEBS Lett. Volume 407
Tavazoie, S.F., Tavazoie, M.F., Mcintosh, J.M., Olivera, B.M., Yoshikami, O., (1997) Differential block of nicotinic synapses on B versus C neurones in sympathetic ganglia of frog by conotoxins MII and ImI
Britain Journal of Pharmacology Volume 120
Jacobsen, R., Yoshikami, D., Ellison, M., J. Martinez, W.R. Gray, G.E. Cartier, K. Shon, Groebe, D.R., Abramson, S.N., Olivera, B.M., Mcintosh, J.M.,, (1997) Differential targeting of nicotinic acetylcholine receptors by novel conotoxins
Biological Chemistry Volume 262
Shon, K., Grilley, M., Jacobsen, R., Cartier, C., Hopkins, G. E., Gray, W. R., Watkins, M., D.R. Hillyard, D. R., Rivier, J., Torres, D., Yoshikami, D., Olivera, B.M., (1997) A noncompetitive peptide inhibitor of the nicotinic acetylcholine receptor from Conus purpurascens venom
Biochemistry Volume 36
Shon, K., Koerber, S. C., Rivier, J.E., Olivera, B.M. and Mcintosh, J.M., (1997) Three-dimensional solution structure of a-conotoxin MII, an a-3/2 neuronal nicotinic receptor-targeted ligand
Biochemistry Volume 36
Kim, M., Baro, D.J., Lanning, C.C., Doshi, M., Farnham, J., Mosko,vitz, H.S., Peck, I.H., Olivera, B.M., Harris-Warrick, R.M., (1997) Alternative splicing in the pore-forming region of shaker potassium channels
Journal of Neuroscience
Shon, K., Stocker, M., Terlau, H. Stiihmer, W., Jacobsen, R., Walker,E., Grilley, M., Watkins, M., Hillyard, D.R., Gray, W.R., Olivera, B.M., (1998) K-Conotoxin PVIIA is a peptide inhibiting the Shaker K' channel
Journal of Biological Chemistry Volume 273
Jacobsen, R., Jimenez, M., Watkins, G.M., Cruz, L.J., Olivera, B.M., (1998 ) The contryphans, a-Dtryptophan-containing family of Conus peptides: Interconversion between conformers
Journal of Peptide Research Volume 51
Bandyopadhyay, P.K., Colledge, C. J., Walker, E.S., Zhou, L.M., Hillyard D.R., Olivera, B.M., (1998) Conantokin-G precursor and its role in y-carboxylation by a vitamin K-dependent carboxylase from a Conus snail
Journal of Biological Chemistry Volume 273
Shon, K-J., Olivera, B.M., Watkins, M., Jacobsen, R.B., Gray, W.R., Floresca, C.Z., Cruz, L.J., Hillyard, D.R., Brink, A., Terlau, H., Yoshikami, D., (1998) Conotoxin PII/A, a new peptide for discriminating among tetrodotoxin-sensitive Na channel subtypes
Journal of Neuroscience Volume 18
Craig, G., M., Akhtar, R., Julius, D. and Olivera, B.M. , () Inactivation of a serotinin-gated ion channel by a polypeptide toxin from marine snails
Science Volume 281
Lopez, M.G., Montiel, C., Herrero, CJ., Garcia-Palomero. E., Mayorgas, L., Hermlndez-Guijo, J.M., Villarroya, M., Olivares, R. Gandia, L., McIntosh, J.M. Olivera, B.M. and Garcia, AG., (1998 ) Unmasking the functions of the chromaffin cell, a nicotinic receptor by using short pulses of acetylcholine and selective blockers
Proc. Natl. Acad. Sci. USA. Volume 95
Luo, S., Kulak, L. M., Cartier, G. E., Jacobsen, R. B., Yoshikami, D., Olivera, B.M. and McIntosh, L.M. , (1998 ) a-Conotoxin Au/B selective blocks a3B4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release
J. Neurosci. Volume 18
Craig, AG., Zafaralla, G., Cruz, L. J., Santos, A. D., Hillyard, D. R., Dykert, J., Rivier, J. E., Gray, W. R., Imperial, J., DelaCruz, R. G., Sporning, A., Terlau, H., West, P. J., Yoshikami, D. and Olivera, B.M., (1998 ) An O-glycosylated neuroexcitatory Conus peptide
Biochemistry Volume 37
Ramirez, L.M., Schwarzacher, S.W., Pierrefiche, O., Olivera, B.M., Richter, D.W., (1998 ) Selective lesioning of the cat preBotzinger complex in Vivo eliminates breathing but not gasping
Journal of Physiology Volume 507
Craig, AG., Norberg, T., Griffin, D., Hoeger, E., Akhtar, M., Schmidt, K., Low, W., Dykert, L., Richelson, E., Navarro, V., Mazella, J., Watkins, M., Hillyard, D., Imperial, J. Cruz, LJ. and Olivera, B.M. , ( 1999 ) Contulakin-G. an O-glycosylated invertebrate neurotensin
J. Biol. Chem. Volume 274
Mcintosh, J.M., Olivera, B.M. and Cruz, L.J. , ( 1999 ) Conus peptides as probes for ion channels
Methods Enzymol. Volume 294
Jacobsen, RB., Jimenez, E. E., DelaCruz, R.G.E. Gray, W. R., Cruz, L.J. and Olivera, B.M., ( 1999 ) A novel D-leucine-containing Conus peptide: diverse confonnational dynamics in the contryphalt family
J. Peptide Res. Volume 54
Terlau, H., Boccaccio, A., Olivera, B.M., Conti, F., (1999) The block of Shaker K+ channels by k-conotoxin PVIIA is state dependent
Journal of Biological Chemistry Volume 114
Walker, C., Steel, D., Jacobsen, R.B., Lirazan, M.B., Cruz, L.J., Hooper, D., Shetty, R., Dela Cruz, R.C., Nielsen, J.S., Zhou, L.M., Bandyopadhyay, P., Craig, A., Olivera, B.M., (1999) The T-superfamily of conotoxins
Journal of Biological Chemistry Volume 274
Craig, A.G., Bandyopadhyay, P., Olivera, B.M., (1999) Post-translationally modified neuropeptides from Conus venoms
European Journal of Biochemistry Volume 264
Pallaghy, P.K., He, W., Jimenez, E.E., Olivera, B.M., Norton, R.S., (2000) Structures of the contryphan family of cyclic peptides. Role of electrostatic interactions in cis-tran isomerism
Biochemistry Volume 39
Hooper, D., Lirazan, M.B., Schoenfeld, R., Cook, B., Cruz, L.J., Olivera, B.M., Bandyopadhyay, P., (2000 ) Post-translational modification: a two dimensional strategy for molecular diversity of Conus peptides
Peptides for the New Millellnium: Proceedings of the Sixteenth American Peptide Symposium, The Netherlands
Mclntosh, J.M., Corpuz, G.O., Layer, R.T., Garretl, J.E., Wagstaff, J.D., Bulaj, G., Vyazovkina, A., Yoshikami, D., Cruz, L.J., Olivera, B.M., (2000 ) Isolation and characterization of a novel Conus peptide with apparent anti nociceptive activity
Journal of Biological Chemistry Volume 275
Olivera, B.M., (2001) Conotoxins, in retrospect
Toxicon Volume 39
Olivera, B.M., et. al., (2001) Contryphans frour Conus textile venom ducts
Toxicon Volume 39
Olivera, B.M., et. al., (2001) On a potential global role for vitamin K-dependent y-carboxylation in animal systems, evidence for a y-glutamyl carboxylase in Drosophila
Journal of Biological Chemistry Volume 276
Kulak, J.M., Mclntosh, D., Yoshikamni, D., Olivera, B.M. , (2001) Nicotine-evoked transmitter release in synaptosomes: functional association of specific presynaptic acetylcholine receptors and voltage-gated calcium channels
Journal of Neurochemistry Volume 77
Jones, R.M., Cartier, G.E., Mcintosh, J.M., Bulaj, G., Farrar, V.E., Olivera, B.M., (2001) Composition and therapeutic utility of conotoxins from genus Conus
Patent status 1996-2000. Exp. Opin. Ther. Patents., Volume 11
Azimi-Zonooz, A., Kawa, E.B., Dowell, E.D., Olivera, B.M. , (2001) Autoradiographic localization of N-type VGCCs in gerbil hippocampus and failure of conotox in MVIIA to attenuate neuronal injury after transient cerebral ischemia
Brain Research Volume 907
Espiritu, DJ.D., Watkins, M., Dia-Monje, V., Cartier, G.E., Cruz, L.J., Olivera, B.M., (2001) Venomous cone snails: molecularv phylogeny and the generation of toxin diversity
Toxicon (in press)
Espiritu, J.D., Cruz, L.J., Cartier, G.E., Olivera, B.M., (2001) Venomous gastropods: Conus, conoideans and other neogastropod families
Bollettino Malacologico (In press)
Maillo, M., Aguilar, M.B., Lopez-Vera, E., Craig, A.G., Bulaj, G., Olivera, B.M., Heimer de la Cortera, E.P., (2001) Conorfamide, a Conus venom peptide belonging to the RFamide family of neuropeptides
Toxicon (in press)
Papers Presented:
- Enzymatic Cleavage and Repair of Transfonning DNA, National Academy of Science, USA
- Venomous Gastropods: Conus, Conoideans and other Neogastropod Families, Systematics, Phylogeny and Biology of the Neograstropoda, 3rd International Workshop on Malacology, Bolletino Malacologico
- Replication of oX174 DNA by Escherichia coli PoIA-in vitro, National Academy of Science, USA
- Structure-Activity Relationships in a-Conotoxins: A model , Peptides: Structure and Function, C.M. Deber, V.I. Hruby and K.D. Kopple (eds.), The 9th American Peptide Symposium, Pierce Chemicals Pubs
- Conus Peptides, a Pharmacologically Diverse Class of Marine Natural Products , 7th Asian Symposium on Medicinal Plants, Spices and Other Natural Products, Manila, Philippines
- Post-translational Modification: A two Dimensional Strategy for Molecular Diversity of Conus peptides, 16th American Peptide Symposium, The Netherlands
Awards:
- Academician, NAST-DOST, 2004
- Scientist of the Year (Outstanding Achievements and Contributions to American Science), Harvard Foundation, 2007
- Most Outstanding Alumnus, Caltech, 2002
- Outstanding UP Alumnus, during UP Centennial Celebration, University of the Philippines
- Fulbright Scholar, , 1961
- Damon Runyon Fellow, , 1966-1968
- Ten Outstanding Young Men Award, Jaycees, 1968
- Eli Lilly Unrestricted Research Award, , 1968-1970
- American Cancer Society Research Award, , 1975-1980
- Alexander Von Humboldt Foundation Senior US Scientist Award, , 1978
- UP Chemical Society Outstanding Alumnus Award, , 1982
- NIH, Biochemistry Study Section, , 1980-1983
- Cellular and Molecular Basis of Disease Review Committee, National Institute of Health, 1982-1986
- Editorial Board, Journal of Toxinology-Toxin Reviews, 1990-1993
- Visiting Committee, Deputy of Molecular Biology and Biochemistry, Harvard University, 1988-1995
- Utah Medal for Science and Tech., , 1991
- E.E Just Lecturer, American Society of Cell Biologists, 1996
- DeWitt Stetten, Jr. Lecuturer, NIGMS, 1996
- Advisory Committee to the NIH Director, National Institute of Health, 1996-1999
- American Association for the Advancement of Science, Council Member, , 1999-2001
- Lorraine Morrow Kelly Distinguished Lecturer, University of Texas, 2001
- Editorial Board, Toxicon, 2000
- Balik Scientist Awardee, DOST, 2008